Fenotipo normopeso obeso en gestantes y condición trófica del recién nacido

Introducción: En la actualidad, una epidemia global paralela coexiste con la pandemia de obesidad; en ella altos niveles de adiposidad general se presentan en organismos de peso corporal adecuado. En embarazadas el diagnóstico temprano de tal fenotipo de normopeso obeso permitiría predecir futuras complicaciones. Objetivo: Determinar los rasgos antropométricos y metabólicos que distinguen a las gestantes normopeso obesas y su relación con la condición trófica al nacer. Métodos: Se realizó un estudio observacional analítico transversal. De una población de 526 gestantes aparentemente saludables en edad reproductiva óptima, se obtuvo una muestra de 358 metabólicamente saludables, que se estratificó en subgrupos: 163 normopeso saludables y 195 normopeso obesas, en las que se estudiaron variables antropométricas, analíticas, ultrasonográficas y la condición trófica neonatal. Se utilizaron métodos teóricos, empíricos y estadísticos. Resultados: Las gestantes del fenotipo normopeso obesas mostraron valores superiores de CCi, Índice CCi/T, %GC, Suma de pliegues cutáneos tricipital y subescapular y del PAL. En ellas las grasas subcutánea y pre-peritoneal fueron superiores, tuvieron mayor frecuencia de nacimientos grandes para la edad gestacional. Conclusiones: El fenotipo normopeso obesas en las gestantes se distingue por rasgos antropométricos, ultrasonográficos y metabólicos de obesidad central y en consecuencia mayor frecuencia de nacimientos grandes para la edad gestacional.

Introduction: At the present time it exists, a parallel global epidemic to the pandemic of obesity; given by normal corporal weight and high levels of general adiposity. Their identification like phenotype of obesity allows predicting risks that can affect the development of the pregnancy. Objective: To determine the anthropometric and metabolic features those distinguish to the obese normal weight pregnant and their relationship with the newborn size. Methods: An observational analytic traverse study was conducted. Of a population of 526 seemingly healthy pregnant in optimal reproductive age, a sample of 358 metabolically healthy ones was obtained, that was stratified in 163 normal-weight healthy (HNW) and 195 obese normal-weight phenotype (ONW), in those anthropometric, metabolic and ultrasonographic variables was studied and the newborn condition. Theoretical, empiric and statistical methods were used. Results: The phenotype ONW in pregnant showed superior securities of WC, Index WC/H, % BF, Sum of tricipital and subescapular skin folds and of the LAP. In them the subcutaneous and pre-peritoneal fats were superior and they had bigger frequency of big births for the gestational age. Conclusions: The phenotype ONW in the pregnant is distinguished for anthropometric, metabolic and ultrasonographic features of central obesity and it is associated with the Big babies for the age gestacional at birth condition.

Macrosomía fetal y factores de riesgo asociados en la provincia Camagüey

Introducción: La macrosomía fetal, de manera tradicional, ha sido definida por un peso arbitrario al nacer; la misma, ya sea definida por un límite de peso o grande para la edad gestacional, se asocia con numerosas complicaciones perinatales y maternas. Objetivo: Describir los factores de riesgo asociados a la macrosomía fetal en los partos del Hospital Universitario Ginecobstétrico Provincial Ana Betancourt de Mora durante el año 2019. Métodos: Se realizó un estudio observacional descriptivo de corte transversal. El universo quedó constituido por la totalidad de gestantes que tuvieron recién nacidos con peso al nacimiento mayor o igual a 4 000 gramos, el cual ascendió a 526 gestantes. Se utilizó estadística descriptiva. Se calculó media y desviación estándar a las variables cuantitativas. Resultados: Las gestantes estudiadas tenían una media de edad de 27,86 años y un IMC a la captación como promedio de 26,77 con un valor medio de ganancia de peso de 13,68 Kg. Entre los 26 y 35 años hubo 290 gestantes con recién nacidos macrosómicos, respecto a la paridad las que paren sin experiencia de este reunió a 222 grávidas. En las embarazadas catalogadas de sobrepeso con ganancia de 10 a 15 kg se reúnen 104 de los recién nacidos macrosómicos. Respecto al tipo de parto la cesárea representó el 61,4 %. Se observó en 40 gestantes la presencia de diabetes gestacional o pregestacional y preeclampsia respectivamente. Conclusiones: La ganancia excesiva de peso en gestantes con evaluación nutricional de sobrepeso u obesas tuvo la mayor incidencia en la génesis de la macrosomía en los recién nacidos.

Introduction: Fetal macrosomia has traditionally been defined by an arbitrary birth weight. Fetal macrosomia, whether defined by borderline weight or large for gestational age, is associated with numerous perinatal and maternal complications. Objective: To describe the risk factors associated with fetal macrosomia in deliveries at Ana Betancourt de Mora Provincial Gyneco-Obstetric University Hospital during 2019. Methods: A cross-sectional descriptive observational study was carried out. The study universe was made up of all pregnant women who had newborns with a birth weight greater than or equal to 4 000 grams, which amounted to 526 pregnant women. Descriptive statistics were used. Average and standard deviation were calculated for the quantitative variables. Results: The studied pregnant women had an average age of 27.86 years and an average BMI at uptake of 26.77 with an average value of weight gain of 13.68 Kg. Between 26 and 35 years there were 290 pregnant women with newborn macrosomic births, with respect to parity those who give birth without experience of this brought together 222 gravid women. In pregnant women classified as overweight with a gain of 10 to 15 kg, 104 of the macrosomic newborns are gathered. Regarding the type of delivery, cesarean section represented 61.4%. The presence of gestational or pregestational diabetes and preeclampsia, respectively, was observed in 40 pregnant women. Conclusions: The excessive weight gain in pregnant women with nutritional evaluation of overweight or obese were those that had the highest incidence in the genesis of macrosomia in newborns.

Exercises down regulate Toll-like receptor 4 signaling pathway in obese and overweight pregnant women / 中华围产医学杂志

Objective:To explore the effect of exercise intervention on regulation of Toll-like receptor 4 (TLR4) signaling pathway in overweight and obese pregnant women.Methods:The cohort was based on a randomized controlled trial (RCT) carried out by the same research group in Peking University First Hospital from December 2014 to July 2016. Overweight and obese patients who delivered by elective cesarean section without pregnancy complications were recruited, among which 12 cases in the exercise group and 11 cases in the control group were selected. Real-time polymerase chain reaction, Western Blot, and Luminex experiments were used to compare the expression of TLR4-myeloid differentiation factor 8(MyD88)-nuclear factor-κB(NF-κB) pathway in peripheral blood mononuclear cell (PBMC), rectus abdominis muscle, omental adipose, and subcutaneous adipose, as well as the levels of inflammatory factors (TNF-α, IL-1β, IL-10) in plasma between the two groups. Two independent samples t-test, generalized estimating equation, Chi-square test, and Pearson correlation analysis were adopted for statistical analysis. Results:(1) The expression of inflammatory factors TNF-α and IL-1β in the exercise group showed a downward trend compared with the control in the second and third trimester, but none of the differences were statistically significant (all P>0.05). (2) The mRNA expression of TLR4, MyD88, and NF-κB and the protein expression of TLR4 and NF-κB in PBMC of the exercise group were significantly lower than those in the control group during pregnancy (TLR4 mRNA: 0.06±0.03 vs 0.10±0.04 in the second trimester, 0.05±0.02 vs 0.11±0.05 in the third trimester, χ2=8.07; MyD88 mRNA: 0.09±0.03 vs 0.11±0.03 in the second trimester, 0.10±0.04 vs 0.17±0.06 in the third trimester, χ2=5.81; NF-κB mRNA: 0.10±0.03 vs 0.17±0.08 in the second trimester, 0.08±0.03 vs 0.20±0.08 in the third trimester, χ2=14.71; TLR4 protein: 1.7±0.5 vs 1.9±0.8 in the second trimester, 1.7±0.4 vs 2.3±0.8 in the third trimester, χ2=5.83; NF-κB protein: 1.0±0.4 vs 1.5±0.4 in the second trimester, 1.2±0.3 vs 1.5±0.5 in the third trimester, χ2=4.73; all P<0.05). Moreover, the differences in the mRNA expression of TLR4, MyD88, and NF-κB and TLR4 protein expression in PBMC between the two groups gradually increased. (3) NF-κB in rectus abdominis and omental adipose tissue (0.04±0.02 vs 0.08±0.04, t=－3.72; 0.25±0.05 vs 0.63±0.21, t=－5.41; both P<0.05) and TLR4 and MyD88 in subcutaneous adipose tissue (0.12±0.03 vs 0.30±0.10, t=－5.30; 0.24±0.09 vs 0.44±0.08, t=－5.38; both P<0.05) were observed a decreased mRNA level in the exercise group compared with the control group. The protein level of MyD88 and NF-κB in omental adipose tissue and NF-κB in subcutaneous adipose tissue in the exercise group were significantly lower than those in the control group (1.1±0.5 vs 2.0±0.8, t=－3.15; 1.3±0.5 vs 2.0±0.9, t=－2.23; 1.2±0.5 vs 1.9±0.8, t=－2.80, all P<0.05). (4) The expressions of TLR4 and NF-κB mRNA ( r=0.453 and 0.485) in rectus abdominis muscle, NF-κB mRNA, TLR4 and MyD88 protein ( r=0.539, 0.437 and 0.527) in omental adipose in the two groups were positively correlated with the level of fasting blood glucose ( P<0.05). Conclusions:Regular exercise during pregnancy can down-regulate the expression and activation of the TLR4-MyD88-NFκB pathway in overweight and obese pregnant women. The expression of related factors along this pathway has a certain correlation with fasting blood glucose.

Obesidad materna como factor de riesgo de obesidad infantil / Maternal obesity as a risk factor for childhood obesity

Introducción: diversos factores ambientales se han relacionado con el incremento en la frecuencia de obesidad infantil en los últimos años. Objetivo: determinar los factores maternos, socioeconómicos y de estilo de vida asociados al sobrepeso/obesidad en niños de 5 a 10 años. Metodología: se realizó un estudio transversal analítico en 153 niños de ambos sexos a los que se les midió peso, talla, índice de masa corporal, presión arterial, glucosa capilar y la presencia de acantosis nigricans. Se compararon los factores entre niños eutróficos y niños con sobrepeso/obesidad a través de Chi cuadrada o t de Student y se realizó una regresión logística para determinar los factores asociados al sobrepeso/obesidad del niño. Resultados: el 30.7% de los niños presentó sobrepeso/obesidad, en ellos se encontró mayor frecuencia de acantosis nigricans y mayores cifras de presión arterial sistólica. El predictor de obesidad infantil fue la obesidad materna, el riesgo de obesidad entre niños de madre con obesidad fue OR: 1.261 (IC95%: 1.047-1.518). Conclusiones: la obesidad materna incrementa el riesgo de obesidad infantil.

Introduction: Several environmental factors have been related to the increase in the frequency of childhood obesity in recent years. Objective: To determine maternal, socioeconomic and lifestyle factors associated with overweight/obesity in children 5 to 10 years oíd. Methods: A cross-sectional analytical study was performed with 153 children of both sexes, measuring weight, height, body mass índex, blood pressure, casual capillary glucose and the presence of acantosis nigricans. Factors were compared between eutrophic children and those with overweight/obesity through Chi-square test or Student's t test, and logistic regression was performed to determine the factors associated with the child's overweight/obesity. Results: 30.7% of the children presented overweight/obesity. In them acantosis nigrica higher systolic blood pressure were found more frequently. The predictor of childhood was maternal obesity; the risk of obesity among children with mothers with obesity it \a 1.261 (95%CI: 1.047-1.518). Condusions: Maternal obesity increases the risk of childhood obesity.

Ganho de peso na gestação, segundo estado nutricional prévio e idade de puérperas atendidas na maternidade de um hospital público de Macaé, Rio de Janeiro / Weight gain during pregnancy, according to previous nutritional status and age of postpartum women assisted in the maternity department of a public hospital in Macaé, Rio de Janeiro

Introdução: A gestação é uma etapa fisiológica que requer acompanhamento de saúde adequado, com vistas ao desfecho positivo para mãe e bebê. Dentre outros cuidados previstos no acompanhamento pré-natal, o ganho de peso é parâmetro a ser monitorado sistematicamente, diante de sua relevância para a saúde materno-infantil e da relação entre ganho de peso inadequado e intercorrências na saúde. Objetivo: Descrever o perfil de ganho de peso gestacional de puérperas assistidas em uma maternidade pública, segundo estado nutricional prévio e idade materna. Método: Estudo epidemiológico transversal descritivo, de base primária (prontuário hospitalar) e secundária (entrevista), realizado em 2014, com amostra de 113 mulheres de 20 a 40 anos com até 48h pós-parto. O estado nutricional pré-gestacional foi avaliado por meio do Índice de Massa Corporal (IMC) e a avaliação da adequação do ganho de peso gestacional considerou as recomendações do Institute Of Medicine (IOM). Resultado: 73,5% tinham idade entre 20-29 anos; 69,9% realizaram seis ou mais consultas de pré-natal e 42,2% tinham excesso de peso (sobrepeso ou obesidade) prévio à gestação. O estado nutricional pré-gestacional, segundo idade, revelou que 35,5%(n=79) daquelas entre 20-29 anos e 60%(n=30) das entre 30-40 anos apresentavam excesso de peso prévio. Houve associação significativa (p<0,01) entre as variáveis "ganho de peso gestacional" e "estado nutricional prévio". Dentre as que tiveram ganho de peso excessivo, 73,1% tinham excesso de peso prévio. Conclusão: Parte expressiva das puérperas já possuía excesso de peso e teve ganho ponderal excessivo na gestação, sobretudo as mais velhas. Sugerem-se a idade materna e o estado nutricional prévio como fatores determinantes do ganho de peso e recomendam-se maior capilaridade e cobertura do acompanhamento nutricional pré-natal no sistema público de saúde como possibilidade de enfrentamento do ganho de peso excessivo, que contribui para o agravamento da epidemia de obesidade no Brasil. (AU)

Introduction: Pregnancy is a physiological stage that requires adequate health monitoring, with a view to achieving a positive outcome for the mother and the baby. Among prenatal care activities, regular monitoring of weight gain is important because of the role such parameter plays in maternal and child health; moreover, inadequate weight gain may lead to health complications. Objective: To describe the pattern of gestational weight gain of postpartum women assisted at a public maternity hospital, according to their previous nutritional status and maternal age. Method: Descriptive cross-sectional epidemiological study, whose data were collected from primary (hospital record) and secondary (interview) sources, in 2014, with a sample of 113 women aged 20 to 40 years up to 48 hours after childbirth. Pregestational nutritional status was assessed using the Body Mass Index (BMI), and gestational weight gain adequacy was assessed on the basis of the recommendations of the Institute of Medicine (IOM). Result: 73.5% were aged 20-29 years; 69.9% made six or more prenatal visits, and 42.2% had excess weight (overweight or obese) prior to pregnancy. Agespecific data on pregestational nutritional status showed that 35.5% (n = 79) of the women between 20-29 years old and 60% (n = 30) of those between 30-40 years old had previous excess weight. There was a significant association (p <0.01) between the variables "gestational weight gain" and "previous nutritional status". Among those who had excess weight gain, 73.1% had previous excess weight. Conclusion: Most of the postpartum women had previous excess weight, and had excess weight gain during pregnancy - especially the older ones. Maternal age and previous nutritional status can be considered as determinants of weight gain. Also, widespread adoption and coverage of prenatal nutritional monitoring are needed in the public health system to help control excessive weight gain, which may aggravate the obesity epidemic in Brazil. (AU)